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Transplantation and Immunology Research Network

american society of transplantation

Clinical Trials in Transplantation

The American Society of Transplantation and its Transplantation & Immunology Research Network are pleased to highlight new clinical trials in transplantation that are currently enrolling or will be in the near future. This service is a benefit of participation in AST’s Corporate Affiliates Program.

Trial Name:

Astagraf XL® to Understand the Impact of Immunosuppression on De Novo DSA Development and Chronic Immune Activation in Kidney Transplantation (ASTOUND)

Sponsor:

Astellas Pharma Global Development, Inc.

Purpose:

This study will compare the incidence of a two-part composite endpoint consisting of de novo donor specific antibody formation or a designation of “immune activation” on peripheral blood molecular profiling in patients maintained on twice daily, immediate-release tacrolimus versus those maintained on Astagraf XL in the first two years post-transplant.

Study Type: Interventional

Estimated Enrollment: 550

Target Completion Date: October 2019

For More Information: https://clinicaltrials.gov/ct2/show/NCT02723591?term=ASTOUND&rank=1


Trial Name:

A Randomized Double-blind Placebo-controlled Study to Evaluate the Efficacy and Safety of Cinryze® (C1 Esterase Inhibitor [Human]) for the Treatment of Acute Antibody-mediated Rejection in Kidney Transplant Patients

Sponsor:

Shire

Purpose:

To evaluate the efficacy of Cinryze® given for the treatment of acute antibody-mediated rejection (of renal allograft) (AMR) in kidney transplant recipients as measured by the proportion of subjects with new or worsening transplant glomerulopathy (TG) within 6 months.

Study Type: Interventional

Estimated Enrollment: 112

Target Completion Date: February 2022

For More Information: https://clinicaltrials.gov/ct2/show/NCT02547220